International Review of Ophthalmology ›› 2014, Vol. 38 ›› Issue (6): 380-385.doi: 10.3760/ cma. j. issn.1673-5803.2014.06.005

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Adipose derived stem cells induced RPE like cells in vitro and its research progress on treatment of age-related macular degeneration

LU Yang, GU Ping, LUO Min   

  1. Department of Ophthalmology, Ninth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200011, China
  • Received:2014-05-04 Online:2014-12-22 Published:2014-12-26
  • Contact: LUO Min, Email: qiangson@sh163.net

Abstract: Agerelated macular degeneration (AMD), which is triggered by the destruction of retinal pigment epithelium cells (RPE cells), has become the leading cause of vision loss in developed countries. Adiposederived stem cells (ADSC) have the potential of multidirectional differentiation. Researches of these years have shown that ADSC can be differentiated into RPE cells and express the markers of RPE cells with the help of retinal cell inducing factors. Animal models have confirmed the involvement of ADSC in repairing the RPE, which may open a new era in the treatment of AMD.   (Int Rev Ophthalmol, 2014, 38:   380-385)